海绵剂是一种吸收能力强、重量轻、密度低,可用于辅助止血、治疗创伤,并可负载药物以提高治疗效果的网状固体制剂。由于固体海绵具有疏松的多孔结构、较强的液体吸收能力及良好的气体透过性,当前正以独特的优势广泛应用于创伤止血。由白及多糖、壳聚糖等具有生物活性的天然高分子材料制备的固体海绵,其自身也可发挥促愈合、抗菌等药效功能。更为重要的是,固体海绵作为药物递送载体发挥药物传递功能逐渐被学界重视。总体而言,固体海绵在止血、外伤修复;组织工程、药物传递,及其自身药理活性等方面表现出良好的开发潜能。然而,目前关于此类型制剂的研究综述尚未见系统报道。因此,笔者从固体海绵基质材料入手,围绕止血及其他功能开发、现有评价指标及性能影响因素等方面做一论述,以期对固体海绵剂的发展提供一定参考。
Abstract
Sponge, a kind of reticular porous solid agent with the characteristics of strong absorption capacity, light weight and low density, can be used to assist hemostasis, treat trauma, and improve the therapeutic effect with loading drugs. Due to its loose porous structure, strong liquid absorption capacity and good gas permeability, solid sponge is widely applied to wound hemostasis with unique advantages.The solid sponge, which is made of bioactive natural polymer materials such as Bletilla striata polysaccharide and chitosan, can also promote healing and exert antibacterial effects. More importantly,as a drug delivery carrier, solid sponge has been paid more attention. In sum, solid sponge has great potential in hemostasis, wound repair, tissue engineering, drug delivery, as well as its own pharmacological activities.However, the systematic research on solid sponge has not been reported. Therefore, this paper will start from the matrix materials of solid sponge, focusing on its hemostatic and other functional development, the existing evaluation index and performance influencing factors of solid sponge, so as to provide a certain reference for the development of solid sponge.
关键词
固体海绵 /
止血 /
天然高分子 /
组织工程
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Key words
solid sponge /
hemostasis /
natural polymer /
tissue engineering
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参考文献
[1] JIANG P C, LI J, JIANG F D, et al. Selection of sponge forming process[J]. China Pharm(中国药师), 2010, 13(5): 658-659.
[2] ZHANG L J, GUO D Y, TANG Z G, et al. Preparation of sponge agent and its research progress[J]. J Shaanxi Coll Tradit Chin Med(陕西中医学院学报), 2011, 34(3): 66-68.
[3] SCHONAUER C, TESSITORE E, BARBAGALLO G, et al. The use of local agents: bone wax, gelatin, collagen, oxidized celluLose[J]. Eur Spine J, 2004, 13(1): S89-S96.
[4] LIGHT R U, PRENTICE H R. Surgical investigation of a new absorbable sponge derived from gelatin for use in hemostasis[J]. J Neurosurg, 1945, 2(5):435-445.
[5] LAN G Q. Preparation and performance study of chitosan/gelatin composite hemostatic material[D]. Chongqing: Southwest University, 2016.
[6] SI Q Q, HOU C L, JIANG L X, et al. Study on the preparation of chitosan film and its hemostatic properties[J]. Med J Chin PLA(解放军医学杂志), 2002, 27(12):1055-1056.
[7] ISHISAKI A, MATSUNO H. Novel ideas of gene therapy for atherosclerosis: modulation of cellular signal transduction of TGF-beta family[J]. Curr Pharm Des, 2006, 12(7):877-886.
[8] THOMAS S. Alginate dressings in surgery and wound management: part 3[J]. J Wound Care, 2000, 9(4):163-166.
[9] ZHANG B N, CUI Y D, CHEN D J, et al. Research progress of chitin/chitosan medical dressing[J]. Prog Chem Ind(化工进展), 2008,(4): 520-526.
[10] YASUNORI N, LI L Y, MASAAKI T, et al. Localized controlled fibrin glue application with gelatin sponge for hemostasis and dural defect repair: technical note[J]. Interdisciplinary Neurosurgery: Advanced Techniques and Case Management, 2019, 18:100476.
[11] JIANG Y, WANG F H, DUAN Y Y. Research and application progress of polysaccharide hemostatic materials[J]. Med J Chin PLA(解放军医学杂志), 2014, 39(12):1004-1007.
[12] TIAN J G, XIA Z F. Research progress of wound dressing[J]. Med J Chin PLA(解放军医学杂志), 2003,28(5):470-471.
[13] GAO W. Preparation and characterization of methyl starch medical hemostatic sponge[D]. Shanghai: Donghua University, 2009.
[14] GUO S R. Pharmaceutical Polymer Materials(药用高分子材料)[M]. Beijing: People's Medical Publishing House, 2009:62.
[15] DU T T. Research on the preparation technology and performance of medical foam dressings containing hollow silver fibers[D]. Shanghai: Donghua University, 2016.
[16] TANG H D, CHEN Y, LI R L. A nerve growth factor sponge agent and its preparation method: China, 101612113[P]. 2009-12-30.
[17] WANG S S. Composite collagen sponge and preparation method thereof: EP, 2737910[P]. 2018-12-19.
[18] JAYAKUMAR R, PRABAHARAN M, SUDHEESH KUMAR P T, et al. Biomaterials based on chitin and chitosan in wound dressing applications[J]. Biotechnol Adv, 2011, 29(3): 322-337.
[19] HU S, BI S, YAN D, et al. Preparation of composite hydroxybutyl chitosan sponge and its role in promoting wound healing[J]. Carbohydr Polym, 2018, 184:154-163.
[20] WEI W, LIU J, PENG Z, et al. Gellable silk fibroin-polyethylene sponge for hemostasis[J]. Artif Cells Nanomed Biotechnol, 2020, 48(1): 28-36.
[21] LUO Y, DIAO H, XIA S, et al. A physiologically active polysaccharide hydrogel promotes wound healing[J]. J Biomed Mater Res, 2010, 94:193-204.
[22] YUE L, WANG W, WANG Y, et al. Bletilla striata polysaccharide inhibits angiotensin II-induced ROS and inflammation via NOX4 and TLR2 pathways[J]. Int J Biol Macromol, 2016, 89: 376-388.
[23] DONG Y X, LIU X X, DONG L, et al. Study on the hemostatic effect and mechanism of Baiji polysaccharide on hemorrhagic hemorrhage model rats[J]. J China Pharm(中国药房), 2016, 27(31): 4347-4350.
[24] ZHANG Q, QI C, WANG H, et al. Biocompatible and degradable Bletilla striata polysaccharide hemostasis sponges constructed from natural medicinal herb Bletilla striata[J]. Carbohydr Polym, 2019, 15: 226.
[25] CHEN J, LV L, LI Y, et al. Preparation and evaluation of Bletilla striata polysaccharide/graphene oxide composite hemostatic sponge[J]. Int J Biol Macromol, 2019, 130: 827-835.
[26] LEI T, SI M M, SONG Z X, et al. A new type of porous hemostatic material and its preparation method . China, 105709265A. [P]. 2016-06-29.
[27] ZHANG Z, KUANG G, ZONG S, et al. Sandwich-like fibers/sponge composite combining chemotherapy and hemostasis for efficient postoperative prevention of tumor recurrence and metastasis[J]. Adv Mater, 2018, 30(49): e1803217.
[28] GAO C, YANG Y, ZHANG Y, et al. HGF gene delivering alginate/galactosylated chitosan sponge scaffold for three-dimensional coculture of hepatocytes/3T3 cells[J]. DNA Cell Biol, 2020, 39(3): 451-458.
[29] LIU Y, SHU X Z, GRAY S D, et al. Disulfide-crosslinked hyaluronan-gelatin sponge: growth of fibrous tissue in vivo [J]. J Biomed Mater Res A, 2004, 68(1):142-149.
[30] WANG C Y, KUO Z K, HSIEH M K, et al. Cell migration of preosteoblast cells on a clinical gelatin sponge for 3D bone tissue engineering[J]. Biomed Mater, 2019, 15(1):015005.
[31] LE H H. Woven silk-collagen sponge scaffold composite ligament stem/progenitor cell sheet to promote anterior cruciate ligament repair and reconstruction[D]. Hangzhou: Zhejiang University, 2018.
[32] RAO F, YUAN Z, LI M, et al. Expanded 3D nanofibre sponge scaffolds by gas-foamingtechnique enhance peripheral nerveregeneration[J]. Artif Cells Nanomed Biotechnol, 2019, 47(1):491-500.
[33] ZHENG C. Study on the preparation and performance of sponge materials based on aldehyde dextran[D]. Dalian: Dalian University of Technology, 2019.
[34] PAN Y Y. Preparation of Sanzi Chuanghe Sponge Dressing[D]. Guangzhou: Southern Medical University, 2014.
[35] LI S K. Research and preparation of chitosan-based nasal packing hemostatic materials[D]. Beijing:Beijing University of Chemical Technology, 2015.
[36] ZHANG C J, XU Q, XIONG C H, et al. The structure and properties of calcium alginate sponge[J]. Poly Mater Sci Eng(高分子材料科学与工程), 2012, 28(9): 24-27.
[37] WANG H N. Research on porous nano-hydroxyapatite/polyamide 66 composite scaffold for bone tissue engineering[D]. Chengdu:Sichuan University, 2007.
[38] CHEN C, LIU L, HUANG T, et al. Bubble template fabrication of chitosan/poly(vinyl alcohol) sponges for wound dressing applications[J]. Int J Biol Macromol, 2013, 62: 188-193.
[39] QUEEN D, GAYLOR J D, EVANS J H, et al. The preclinicalevaluation of the water vapour transmission rate through burn wound dressings[J]. Biomaterials, 1987, 8(5):367-371.
[40] HUANG X, SUN Y, NIE J, et al. Using absorbable chitosan hemostatic sponges as a promising surgical dressing[J]. Int J Biol Macromol, 2015, 75: 322-329.
[41] YE S, JIANG L, SU C, et al. Development of gelatin/bacterial cellulose composite sponges as potential natural wound dressings[J]. Int J Biol Macromol, 2019, 133:148-155.
[42] WANG H Z. Preparation and properties of konjac glucomannan film and sponge material[D]. Wuhan:Wuhan Textile University, 2013.
[43] QIN S N, CHEN H H, YANG X H, et al. Preparation and pore structure analysis of collagen sponge scaffold for tissue engineering[J]. J Biomed Eng(生物医学工程学杂志), 2010, 27(4): 820-824.
[44] ZHANG S Q, ZHAO X, LU J Y, et al. Research status of absorbable hemostatic materials and related technical requirements[J]. Mil Med(军事医学),2012,36(11): 862-866.
[45] GU B K, PARK S J, KIM M S, et al. Gelatin blending and sonication of chitosan nanofiber mats produce synergistic effects on hemostaticfunctions[J]. Int J Biol Macromol, 2016, 82:89-96.
[46] NAKAMATSU J, TORRES F G, TRONCOSO O P, et al. Processing and characterization of porous structures from chitosan and starch for tissue engineering scaffolds[J]. Biomacromolecules, 2006, 7(12): 3345-3355.
[47] HU Q. Preparation of starch-based medical sponge and research on its structure and properties[D]. Shanghai: Donghua University, 2010.
[48] HU Q, TU X X, MA J H, et al. The effect of heat transfer on the pore structure of starch sponge during freeze-drying process[J]. Mater Guide(材料导报), 2010, 24(S1):401-404.
[49] KIU W Y, GUO L L, LIU Z Y, et al. Preparation and performance study of oxidized cellulose/chitosan composite sponge[J]. New Chem Mater(化工新型材料), 2019, 47(11): 162-166.
[50] SINKOWAKA A, PLANECKA A. Preparation and characterization of silkfibroin/chitosancomposite sponges for tissueengineering[J]. J Mol Liquids, 2013, 178: 5-14.
[51] QU J G, WANG Y K, XIAO J H. Degradable water retaining agent and preparation method thereof. China, 106749935B[P]. 2019-06-28.
[52] LI D H, LI P X, LUO J H, et al. The effect of crosslinking agent on the performance of composite biological sponge[J]. Chin J Med Instrum(中国医疗器械杂志), 2012, 36(5): 317-320.
[53] CHEN C, LIU L, HUANG T, et al. Bubble template fabrication of chitosan/poly(vinyl alcohol) sponges for wound dressing applications[J]. Int J Biol Macromol, 2013, 62: 188-193.
[54] SATO T. Polysaccharide pseudo-sponge. US. 8389713[P]. 2013-03-05.
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脚注
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基金
国家自然科学基金面上项目资助(81873191)
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